Research Topics




CURRENT TOPICS


全生物共通祖先とさらにそれ以前のタンパク質の解析
Characterization of proteins hosted by the last universal common ancestor (LUCA) and pre-LUCA


祖先タンパク質の実験的な復元
Experimental resurrection of ancient proteins


全生物共通祖先以前のタンパク質のアミノ酸組成
Amino acid repertoire before the last universal common ancestor



合理的設計と進化分子工学、祖先型設計法によるタンパク質の改変:タンパク質の実用化へ向けて
Improvement of protein's properties by rational design and directed evolution: For practical application


好熱菌由来耐熱性タンパク質の低温高活性化
Improvement of the low-temperature activities of thermally stable thermophilic enzymes


祖先型設計法による耐熱性タンパク質の創出
Design of thermally stable proteins by the ancestral design method




熱安定なタンパク質を材料としたナノバイオ工学
Nano-bio engineering using thermally stable proteins

新規タンパク質間相互作用の設計・創出によるタンパク質ナノ繊維の構築と金属結合タンパク質の設計
Creation of a protein nano-fiber and desing of a metal binding surface on a protein



(β/α)8バレルタンパク質
(β/α)8-barrel protein project

合理的設計と進化分子工学による酵素機能の改変
Redesign of an enzyme's activity by rational design and directed evolution


(β/α)8バレルタンパク質の起源と進化および立体構造構築原理の解明
The origin, evolution and folding mechanism of (β/α)8-barrel proteins





Former Topics

click structures


Protein Simplification Engineering

Protein engineering study to explore the evolution and folding mechanism of an enzyme




Protein Folding Mechanism and Local Structure Important for Early Protein Folding




Research Projects at NFRI:
Immobilization and Micro-Patterning of Proteins
Detection of protein-protein interactions with an atomic force microscopy
Extension of a protein molecule by an atomic force microscopy
Amplification of a single DNA fragment using phi29 DNA polymerase




Improvement of Protein Thermostability: Rational Design and Evolutionary Molecular Engineering




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