リンク

研究業績

【英文論文】
1. Chiba T, Tsuchiya T, Mori R, Shimokawa I. Protein Reporter Bioassay Systems for the Phenotypic Screening of Candidate Drugs: A Mouse Platform for Anti-aging Drug Screening. Sensors. 2012, in press.

2. Lee AY*, Chiba T* (*equal contribution), Truong LN, Cheng AN, Do J, Cho MJ, Chen L, Wu X. Dbf4 is a direct downstream target of ATM and ATR to regulate the intra S-phase checkpoint. J Biol Chem. 2012, 287(4):2531-43.

3. Mori R, Ikematsu K, Kitaguchi T, Kim SE, Okamoto M, Chiba T, Miyawaki A, Shimokawa I, Tsuboi T. Release of tumor necrosis factor-α from macrophages is mediated by small GTPase Rab37. Eur J Immunol. 2011, 41:3230-3239.

4. Hayashida T, Komatsu Y, Henmi Y, Yanagihara-Ota K, Kim A, Chiba T, Goto S, Chung HY, Shimokawa I. Modest inhibition of the growth hormone axis does not affect mitochondrial reactive oxygen species generation or redox state, unlike calorie restriction. Geriatr Gerontol. 2011, 496-503

5. Trindade LS, Park S, Komatsu T, Yamaza H, Hayashi H, Mori R, Chiba T, Kuramoto K, Shimokawa I. Down-regulation of hepatic AMP-activated protein kinase and up-regulation of CREB coactivator CRTC2 for gluconeogenesis under calorie-restrictedconditions at a young age. Acta Medica Nagasakiensia, in press.

6. Komatsu T, Trindade LS, Chiba T, Hayashi H, Henmi Y, Ushiroda Y, Mori R, Shimokawa I.Acute stress response modified by modest inhibition of growth hormone axis: a potential machinery of the anti-aging effect of calorie restriction. Mech Ageing Dev. 2011, 132(3):103-109.

7. Chiba T, Tsuchiya T, Komatsu T, Mori R, Hayashi H, Shimano H, Spindler SR, Shimokawa I. Development of a bioassay to screen for chemicals mimicking the anti-aging effects of calorie restriction. Biochem. Biophys. Res. Commun. 2010, 401(2):213-218.

8. Chiba T, Tsuchiya T, Komatsu T, Mori R, Hayashi H, Shimokawa I. Development of Calorie Restriction Mimetics as Therapeutics for Metabolic, Inflammatory, and Neurodegenerative Diseases. Curr. Genomics. 2010, 11:562-567

9. Asai-Akieda S, Zaima N, Ikegami K, Kahyo T, Yao I, Hatanaka T, Iemura S, Sugiyama R, Yokozeki T, Eishi Y, Koike M, Ikeda K, Chiba T, Yamaza H, Shimokawa I, Song S, Matsuno A, Mizutani A, Sawabe M, Chao MV, Tanaka M, Kanaho Y, Natsume T, Sugimura H, Date Y, McBurney MW, Guarente L, Setou M. SIRT1 Regulates Thyroid-Stimulating Hormone Release by Enhancing PIP5Kc Activity through Deacetylation of Specific Lysine Residues in Mammals. PLoS ONE, 2010, 5(7): e11755. doi:10.1371/journal.pone.0011755

10. Yamaza H, Komatsu T, Wakita S, Kijogi C, Park S, Hayashi H, Chiba T, Mori R, Furuyama T, Mori N, Shimokawa I. FoxO1 is involved in the antineoplastic effect of calorie restriction. Aging Cell. 2010, 9:372–382.

11. Chiba T*, Komatsu T, Nakayama M, Adachi T, Tamashiro Y, Hayashi H, Yamaza H, Higami Y, Shimokawa I. Similar metabolic responses to calorie restriction in lean and obese Zucker rats. Mol Cell Endocrinol. 2009, 309(1-2):17-25.

12. Park S, Komatsu T, Hayashi H, Trindade L, Yamaza H, Chiba T, Shimokawa I. Divergent regulation of adipose tissue metabolism by calorie restriction and inhibition of growth hormone signaling. Exp Gerontol. 2009, 44(10):646-52.

13. Chiba T*, Inoue D, Mizuno A, Komatsu T, Fujita S, Kubota H, Guimarães M, Park S, Trindade L, Hayashida T, Hayashi H, Yamaza H, Higami Y, Shimokawa I. Identification and characterization of an insulin receptor substrate 4-interacting protein in rat brain: implications for longevity. Neurobiol Aging. 2009, 30(3):474-82.

14. Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Kuramoto K, Shimokawa I. Calorie restriction initiated at a young age activates the Akt/PKCζ/λ-Glut4 pathway in rat white adipose tissue in an insulin-independent manner. AGE. 2008, 30:293-302.

15. Shimokawa I, Chiba T, Yamaza H, Komatsu T. Longevity Genes: Insights from Calorie Restriction and Genetic Longevity Models. Mol Cells. 2008, 26(5): 427-435.

16. Hayashi H, Yamaza H, Komatsu T, Park S, Chiba T, Higami Y, Nagayasu T, Shimokawa I. Calorie restriction minimizes activation of insulin signaling in response to glucose: potential involvement of the growth hormone-insulin-like growth factor 1 axis. Exp Gerontol. 2008, 43(9):827-32.

17. Chiba T*, Yamaza H, Komatsu T, Nakayama M, Fujita S, Hayashi H, Higami Y, Shimokawa I. Pituitary growth hormone suppression reduces resistin expression and enhances insulin effectiveness: relationship with caloric restriction. Exp Gerontol. 2008, 43(6):595-600.

18. Komatsu T, Chiba T*, Yamaza H, Yamashita K, Shimada A, Hoshiyama Y, Henmi T, Ohtani H, Higami Y, de Cabo R, Ingram DK, Shimokawa I. Manipulation of caloric content but not diet composition, attenuates the deficit in learning and memory of senescence-accelerated mouse strain P8. Exp Gerontol. 2008, 43(4):339-46.

19. Chiba T*, Yamaza H, Shimokawa I. Role of insulin and growth hormone/insulin-like growth factor-I signaling in lifespan extension: Rodent longevity models for studying aging and calorie restriction. Current Genomics. 2007, 8(7):423-428.

20. Chiba T*, Fujita S, Kubota H, Inoue D, Mizuno A, Komatsu T, Yamaza H, Higami Y, Shimokawa I. Identification of fasting-induced genes in the rat hypothalamus: relationship with neuroprotection. Ann NY Acad Sci. 2007, 1119:216-26.

21. Liu E, Alan YL, Chiba T, Olson E, Sun P, Wu X. ATR-mediated S-phase checkpoint prevents DNA rereplication in mammalian cells when the licensing control is disrupted. J Cell Biol. 2007, 179(4):643-57.

22. To K, Yamaza H, Komatsu T, Hayashida T, Hayashi H, Toyama H, Chiba T, Higami Y, Shimokawa I. Down-regulation of AMP-activated protein kinase by calorie restriction in rat liver. Exp Gerontol. 2007, 42(11):1063-71.

23. Chiba T*, Yao J, Higami Y, Shimokawa I, Hosokawa M, Higuchi K. Identification of differentially expressed genes in senescence-accelerated mouse testes by suppression subtractive hybridization analysis. Mamm Genome. 2007, 18(2):105-12.

24. Yamaza H, Komatsu T, To K, Toyama H, Chiba T, Higami Y, Shimokawa I. Involvement of insulin-like growth factor-1 in the effect of caloric restriction: regulation of plasma adiponectin and leptin. J Gerontol A Biol Sci Med Sci. 2007, 62(1):27-33.

25. Park S, Komatsu T, Hayashi H, Yamaza H, Chiba T, Higami Y, Kuramoto K, Shimokawa I. Calorie restriction initiated at middle age improved glucose tolerance without affecting age-related insulin resistance in rat skeletal muscle. Exp Gerontol. 2006, 41(9):837-45.

26. Higami Y, Tsuchiya T, Chiba T, Yamaza H, Muraoka I, Hirose M, Komatsu T, Shimokawa I. Hepatic gene expression profile of lipid metabolism in rats: impact of caloric restriction and growth hormone/IGF-1 suppression. J Gerontol A Biol Sci. 2006, 61(11):1099-110.

27. Komatsu T, Chiba T, Yamaza H, To K, Toyama H, Higami Y, Shimokawa I. Role of leptin signaling in the hypothalamus in the effect of calorie restriction. J Gerontol A Biol Sci. 2006, 61(9):890-8.

28. Tsuchiya T, Higami Y, Komatsu T, Tanaka K, Honda S, Yamaza H, Chiba T, Ayabe H, Shimokawa I. Acute stress response in calorie-restricted rats to lipopolysaccharide-induced inflammation. Mech Ageing Dev. 2005, 126(5):568-79.

29. Wu X, Avni D, Chiba T, Yan F, Zhao Q, Lin Y, Heng H, Livingston D. SV40 T antigen interacts with Nbs1 to disrupt DNA replication control. Genes Dev. 2004, 18(11):1305-16.

30. Yao J, Chiba T, Sakai J, Hirose K, Yamamoto M, Hada A, Kuramoto K, Higuchi K, Mori M. Mouse testis transcriptome revealed using serial analysis of gene expression.
Mamm Genome. 2004, 15(6):433-51.

31. Higami Y, Tsuchiya T, To K, Chiba T, Yamaza H, Shiokawa D, Tanuma S, Shimokawa I. Expression of DNase gamma during Fas-independent apoptotic DNA fragmentation in rodent hepatocytes. Cell Tissue Res. 2004, 316(3):403-7. Epub 2004 Apr 29.

32. Yamaza H, Komatsu T, Chiba T, Toyama H, To K, Higami Y, Shimokawa I. A transgenic dwarf rat model as a tool for the study of calorie restriction and aging. Exp Gerontol. 2004, 39(2):269-72.

33. Shimokawa I, Higami Y, Tsuchiya T, Otani H, Komatsu T, Chiba T, Yamaza H. Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J. 2003, 17(9):1108-9.

34. Shimokawa I, Fukuyama T, Yanagihara-Outa K, Tomita M, Komatsu T, Higami Y, Tuchiya T, Chiba T, Yamaza Y. Effects of caloric restriction on gene expression in the arcuate nucleus. Neurobiol Aging. 2003, 24(1):117-23.

35. Yamaza H, Chiba T, Higami Y, Shimokawa I. Lifespan extension by caloric restriction: an aspect of energy metabolism. Microsc Res Tech. 2002, 59(4):325-30.

36. Chiba T*, Yamaza H, Higami Y, Shimokawa I. Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling. Microsc Res Tech. 2002, 59(4):317-24.

37. Shimokawa I, Higami Y, Utsuyama M, Tuchiya T, Komatsu T, Chiba T, Yamaza H. Life span extension by reduction in growth hormone-insulin-like growth factor-1 axis in a transgenic rat model. Am J Pathol. 2002, 160(6):2259-65.

38. Mizutani J, Chiba T, Tanaka M, Higuchi K, Mori M. Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains. J Hered. 2001, 92(4):352-5.

39. Fu L, Matsuyama I, Chiba T, Xing Y, Korenaga T, Guo Z, Fu X, Nakayama J, Mori M, Higuchi K. Extrahepatic expression of apolipoprotein A-II in mouse tissues: possible contribution to mouse senile amyloidosis. J Histochem Cytochem. 2001, 49(6):739-48.

40. Xing Y, Nakamura A, Chiba T, Kogishi K, Matsushita T, Li F, Guo Z, Hosokawa M, Mori M, Higuchi K. Transmission of mouse senile amyloidosis. Lab Invest. 2001, 81(4):493-9.

41. Wang J, Matsushita T, Kogishi K, Xia C, Ohta A, Chiba T, Nakamura A, Kondo H, Mori M, Hosokawa M, Higuchi K. Wild type ApoA-II gene does not rescue senescence-accelerated mouse (SAMP1) from short life span and accelerated mortality. J Gerontol A Biol Sci Med Sci. 2000, 55(9):B432-9.

42. Umezawa M, Takeda T, Kogishi K, Higuchi K, Matushita T, Wang J, Chiba T, Hosokawa M. Serum lipid concentrations and mean life span are modulated by dietary polyunsaturated fatty acids in the senescence-accelerated mouse. J Nutr. 2000, 130(2):221-7.

43. Chiba T, Kogishi K, Wang J, Xia C, Matsushita T, Miyazaki J, Saito I, Hosokawa M, Higuchi K. Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of amyloid-resistant apolipoprotein A-II. Am J Pathol. 1999, 155(4):1319-26.

44. Xia C, Higuchi K, Shimizu M, Matsushita T, Kogishi K, Wang J, Chiba T, Festing MF, Hosokawa M. Genetic typing of the senescence-accelerated mouse (SAM) strains with microsatellite markers. Mamm Genome. 1999, 10(3):235-8.

45. Shimizu M, Higuchi K, Bennett B, Xia C, Tsuboyama T, Kasai S, Chiba T, Fujisawa H, Kogishi K, Kitado H, Kimoto M, Takeda N, Matsushita M, Okumura H, Serikawa T, Nakamura T, Johnson TE, Hosokawa M. Identification of peak bone mass QTL in a spontaneously osteoporotic mouse strain. Mamm Genome. 1999, 10(2):81-7.

46. Higuchi K, Kogishi K, Wang J, Chen X, Chiba T, Matsushita T, Hoshii Y, Kawano H, Ishihara T, Yokota T, Hosokawa M. Fibrilization in mouse senile amyloidosis is fibril conformation-dependent. Lab Invest. 1998, 78(12):1535-42.

47. Higuchi K, Kogishi K, Wang J, Xia C, Chiba T, Matsushita T, Hosokawa M. Accumulation of pro-apolipoprotein A-II in mouse senile amyloid fibrils. Biochem J. 1997, 325 (Pt 3):653-9.


【和文論文】
1. 森 亮一、間所 俊介、Kim Sang Eun、小松 利光、千葉 卓哉、坪井 貴司、下川 功
マクロファージからのサイトカイン分泌に関与する低分子量 G タンパク質 Rab ファミリーの機能解析.
Biomedical Gerontology, 35, 33-36, 2011.

2. 森 亮一、小松 利光、千葉 卓哉、下川 功
エイジングの分子機構とアンチエイジングの作用点.
Diabetes Frontier, 21(1): 26-31, 2010.

3. 千葉卓哉、下川 功
Neuropeptide Yによる代謝制御と抗老化作用
-ヒトへの応用に向けたCR mimetics開発の標的探索-
基礎老化研究 Vol.33(3): 17-20, 2009

4. 千葉卓哉、下川 功
カロリー制限による抗老化作用:代謝適応仮説とヒトへの応用の可能性
アンチエイジング医学 Vol.5(4): 53-61, 2009

5. 千葉卓哉、山座治義、下川 功
カロリー制限と老化
Surgery Frontier 15 (4): 36-40, 2008

6. 山座治義、千葉卓哉、下川 功
カロリー制限とは
サイエンスに基づいたアンチエイジング(印刷中)

7. 山座治義、千葉卓哉、下川 功
メタボリックシンドロームとカロリー制限:糖代謝を中心に.
新しい眼科学 2008 25:9-14

8. 千葉卓哉、山座治義、下川 功
カロリー制限による寿命延長・抗老化機構−神経内分泌仮説に基づく代謝調節の重要性−
基礎老化研究 Vol. 32, No.3, 2008, 15-20

9. 千葉卓哉、下川 功
カロリー制限による寿命延長の分子機構
医学の歩み Vol. 217 No. 7 2006, 769-773

10. 林 洋子、山座治義、黨 和夫、遠山啓亮、小松利光、千葉卓哉、樋上賀一、下川 功
カロリー制限・GH-IGF-I抑制ラットのグルコース代謝:Adiponectin-AMPKの解析
基礎老化研究 Vol. 29, No.3, 2005, 31-34


【書籍・章】
1. Shimokawa I and Chiba T
Bioactive Foods And Chronic Disease States: Food and longevity genes

2. Shimokawa I, Utsuyama M, Komatsu T, Yamaza H, Chiba T
A transgenic dwarf rat strain as a tool for the study of immunosenescence in aging rats and the effect of calorie restriction.
Fulop T (eds.) Handbook on Immunosenescence, Springer Science Business Media, pp 133-144, 2009

3. 千葉卓哉、山座治義、下川 功
内分泌モデル(GH/IGF-I)動物
老化・老年病研究のための動物実験ガイドブック 基礎老化学会編、アドスリー
p130-138, 2008

4. Chiba T, Kogishi K, Wang J, Xia C, Matsushita T, Hosokawa M, Miyazaki J, Saito I, Sasai Y, Higuchi K, AApoAII amyloid deposition is suppress by adenovirus-mediated overexpression of type B apolipoprotein A-II gene in the mice. Kyle RA, Gertz. eds. Amiloid and Amyloidosis. pp56-58, Parthenon Publishing, New York, 1999.

5. Higuchi K, Kogishi, Wang J, Chen X, Chiba T, Matsushita T, Hoshi H, Kawano T, Ishihara T, Hosokawa M: Fibrization in mouse senile amylidosis is fibril conformation dependent. Kyle RA, Gertz eds. Amiloid and Amyloidosis. pp 47-49, Parthenon Publishing, New York, 1999.



【シンポジウム】
Chiba T: Development of a bioassay system to screen for chemicals mimicking the anti-aging effects of calorie restriction (Invited Lecture). The Nagasaki-Pusan Joint Seminar on Aging Research, Fukuoka, Japan (2011.2.18)

Chiba T: Deletion of neuropeptide Y gene weakens stress resistance and shortens lifespan in calorie-restricted mice (Lecture). The 3rd Nagasaki-Hallym International Joint Meeting on Aging and Neurodegenerative Diseases, Nagasaki, Japan (2010)

Chiba T: Deletion of NPY gene limits the beneficial effects of calorie restriction on stress resistance and lifespan extension (Invited Lecture). Asian Aging Core for LongevityResearch and Education 2010 Jeju Conference, Jeju, Korea (2010.8)

Chiba T: Role of hypothalamic neuropeptide Y in the beneficial effects of calorie restriction.
19th IAGG World Congress of Gerontology and Geriatrics, Paris, France(2009年7月5日-9日)

千葉卓哉:カロリー制限による抗老化作用の分子メカニズム:代謝・老化・寿命調節における中枢の役割 第32回日本基礎老化学会大会 横浜(2009年6月20日)

Chiba T: Anti-aging effects of calorie restriction: Importance of neuroendocrine adaptation. The 2nd Hallym-Nagasaki international joint meeting on aging and neurodegenerative diseases, Seoul, Korea (シンポジスト、2009年2月9日)

Chiba T. Identification and characterization of food deprivation-activated genes and insulin receptor substrate interacting protein in rat hypothalamus by suppression subtractive hybridization analysis. 12th International Association for Biomedical Gerontology Congress, Spetses, Greece (2007年5月22日、20-24日)

千葉卓哉:カロリー制限による寿命延長作用の解明(insulin/IGF-Iシグナルを中心として)第1回エイジング・バイオストレス・メタボリズム研究会 京都(2007年4月9日)

Chiba T: Effect of caloric restriction on zucker obese rats: gene expression and transcription factor activity in the liver, 2006 Conference of the Korean Society for Gerontology -The 6th Korea-Japan Gerontologist Joint Meeting, Chuncheon, Korea (2006年6月22日、22-23日)

千葉卓哉:カロリー制限による抗老化作用−中枢を介したエネルギー代謝との関連−
「脳を守る」研究領域「老化脳可塑性」戦略研究プロジェクト・ミニシンポジウム 長崎(2002年10月)

Chiba T, Kogishi K, Wang J, Xia C, Matsushita T, Miyazaki J, Saito I, Hosokawa M, Higuchi K. Mouse senile amyloid deposition is suppressed by adenovirus-mediated overexpression of type B apolipoprotein A-II gene in the mice. VIIIth International Symposium on Amyloidosis. Rochester, USA(1998年8月)