リンク

研究業績

【論文発表】
1. Li S, Wang H, Jehi S, Wang Z, Truong L, Chiba T, Wang Z, Wu X.
PIF1 promotes break-induced replication to suppress common fragile site instability
EMBO J. 2021;40(8):e104509. doi: 10.15252/embj.2020104509.

2. Saito K, Ito M, Chiba T, Jia H, Kato H.
A Comparison of Gene Expression Profiles of Rat Tissues after Mild and Short-Term Calorie Restrictions
Nutrients. 2021;13(7), 2277. doi: 10.3390/nu13072277

3. Wang Z, Ohata Y, Watanabe Y, Yuan Y, Yoshii Y, Kondo Y, Nishizono S, Chiba T. Taurine improves lipid metabolism and increases resistance to oxidative stress.
J Nutr Sci Vitaminol (Tokyo). 2020;66(4):347-356. doi: 10.3177/jnsv.66.347.

4. Wang Z, Komatsu T, Ohata Y, Watanabe Y, Yuan Y, Yoshii Y, Park S, Mori R, Satou M, Kondo Y, Shimokawa I, Chiba T. Effects of rikkunshito supplementation on resistance to oxidative stress and lifespan in mice. Geriatr Gerontol Int. 2020;20(3):238-247.

5. Li S, Lu H, Wang Z, Hu Q, Wang H, Xiang R, Chiba T, Wu X. ERCC1/XPF Is Important for Repair of DNA Double-Strand Breaks Containing Secondary Structures. iScience. 2019 Jun 28;16:63-78. doi: 10.1016/j.isci.2019.05.017. Epub 2019 May 16.

6. Wang Z, Song Y, Li S, Kurian S, Xiang R, Chiba T, Wu X. DNA Polymerase theta (POLQ) is important for repair of DNA double-strand breaks caused by fork collapse. J Biol Chem, 2019 Mar 15;294(11):3909-3919. doi: 10.1074/jbc.RA118.005188..

7. Nishizono S, Wang Z, Watanabe T, Ohata T, Chiba T. Mechanisms of action of compounds that mimic beneficial effects of calorie restriction such as lifespan extension: Is taurine a promising candidate? J Phys Fitness Sports Med, 2017 6(4): 201-267.

8. Kim SE, Mori R, Komatsu T, Chiba T, Hayashi H, Park S, Sugawa MD. Dencher NA, Shimokawa I. Upregulation of cytochrome c oxidase 1 subunit 6b1 (Cox6b1) and
formation of mitochondrial supercomplexes: Implication of Cox6b1 in the effect of calorie restriction. AGE, 2015 Jun;37(3):9787. doi: 10.1007/s11357-015-9787-8.

9. Shimokawa I, Komatsu T, Hayashi N, Kim SE, Kawata T, Park S, Hayashi H, Yamaza H, Chiba T, Mori R. The life-extending effect of dietary restriction requires Foxo3 in mice. Aging Cell. 2015, 2015 Aug;14(4):707-9. doi: 10.1111/acel.12340.

10. Kamohara R, Yamaza H, Tsuchiya T, Komatsu T, Park S, Hayashi H, Chiba T, Mori R, Otabe S, Yamada K, Nagayasu T, Shimokawa I. Overexpression of the adiponectin gene mimics the metabolic and stress resistance effects of calorie restriction, but not the anti-tumor effect. Exp Gerontol. 2015, 64C:46-54. doi: 10.1016/j.exger.2015.02.011.

11. Okita N, Tsuchiya T, Fukushima M, Itakura K, Yuguchi K, Narita T, Hashizume Y, Sudo Y, Chiba T, Shimokawa I, Higami Y. Chronological analysis of caloric restriction-induced alteration of fatty acid biosynthesis in white adipose tissue of rats. Exp Gerontol. 2015, 63:59-66. doi: 10.1016/j.exger.2015.01.043. Epub 2015 Jan 20.

12. Park S, Fujishita C, Komatsu T, Kim SE, Chiba T, Mori R, Shimokawa I. NPY antagonism reduces adiposity and attenuates age-related imbalance of adipose tissue metabolism. FASEB J. 2014, 28(12):5337-48.

13. Chiba T, Tamashiro Y, Park D, Kusudo T, Fujie R, Komatsu T, Kim SE, Park S, Hayashi H, Mori R, Yamashita H, Chung HY, Shimokawa I. A key role for neuropeptide Y in lifespan extension and cancer suppression via dietary restriction. Sci Rep. 2014, 4:4517. doi:10.1038/srep04517.

14. Chiba T, Dong K, Nishizono S, Shimokawa I. Mechanisms of lifespan extension and preventive effects of calorie restriction on tumor development: Possible link between central neuroendocrine system and peripheral metabolic adaptation. J Phys Fitness Sports Med, 2013, 2(3): 259-266.

15. Chujo Y, Fujii N, Okita N, Konishi T, Narita T, Yamada A, Haruyama Y, Tashiro K, Chiba T, Shimokawa I, Higami Y. Caloric restriction-associated remodeling of rat white adipose tissue: effects on the growth hormone/insulin-like growth factor-1 axis, sterol
regulatory element bin